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Hip Joint Synovial Cyst
Joseph Junewick, MD FACR
over 10 years ago
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Eosinophilic Granuloma

Case Detail

Anatomy: Neck-Face
Joseph Junewick, MD FACR
Diagnostic Category: Neoplasia Benign
Created: over 11 years ago
Updated: over 10 years ago
Tags: PEDS
Modality/Study Types: CT
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7 month old female with palpable right supraorbital lesion.

Case Images


Eosinophilic granulomas


CT – transdiploic left frontal and right superolateral orbital destructive lesions demonstrating uniform soft tissue density.


Langerhans cell histiocytosis (LCH) is the result of uncontrolled proliferation of a bone marrow derived cell in various tissues. The Langerhans cell is characterized by Bierbeck granules on electron microscopy and CD1 and S100 positivity on immunohistochemical evaluation. LCH is the result of an immature immune system; LCH tends to be more severe in young patients.

LCH of bone results in destruction of bone and marrow by infiltration of Langerhans cells, eosinophils, neutrophils and macrophages. Patients present with bone pain and swelling. Bone involvement is present un more than 80% of cases with single or multiple lytic lesions. Any bone can be involved but the skull is most common.

On CT, skull lesions may be punched out, beveled, or occasionally sequestrum. Soft tissue masses often demonstrates enhancement and may be associated with dural extension. Calcification are rare.


Azouz EM, et al. Langerhans’ cell histiocytosis: Pathology, imaging and treatment of skeletal involvement. Pediatric Radiology 2005; 35(2):103-115.

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