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Joseph Junewick, MD FACR
over 8 years ago
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Wegener's Granulomatosis

Case Detail

Anatomy: Chest
Junewick
Joseph Junewick, MD FACR
Diagnostic Category: Infectious-Inflammatory
Created: over 5 years ago
Updated: over 5 years ago
Tags: PEDS
Modality/Study Types: CT
Activities:
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History

15 year old male with cough.


Case Images


Diagnosis

Wegener’s Granulomatosis

Findings

CT – Multiple angiocentric nodular masses; cavitated masses have thick irregular walls.

Discussion

Wegener granulomatosis is a systemic autoimmune disease characterized by granulomatous vasculitis of the upper and lower respiratory tracts, glomerulonephritis, and small-vessel vasculitis. Lung disease develops in most patients. The most common radiographic manifestation of Wegener granulomatosis is multiple nodules or irregularly marginated masses with no zonal predominance. The nodules or masses are usually multiple but can be solitary. Cavitation occurs in approximately 50%; the cavities usually have irregular, thick walls. The nodules or cavities may resolve completely or result in a scar. Peripheral infarctions, hemorrhage and pneumonia may also be seen. Pleural effusion and adenopathy are uncommon. Submucosal granulomas may occur in the trachea and bronchi.

Reference

Mayberry JP, Primack SL, Muller NL. Thoracic Manifestations of Systemic Autoimmune Diseases: Radiographic and High-Resolution CT Findings. Radiographics (2000); 20:1623-1635.



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