Hosting 728 files, 2951 images, and 4 contributors.

Random Case

Highly primitive malignant neoplasm of the Pancreas
Joseph Junewick, MD FACR
over 11 years ago
Enter A Workflow
Standard2   Academic2

Please choose a workflow. A standard workflow allows you to browse the repository with full case detail; the academic workflow allows you to browse the repository with limited case detail revealed. Double click on the images to launch image viewer.

ARSt Case Repository

Fanconi Anemia

Case Detail

Anatomy: Brain-Spine
Joseph Junewick, MD FACR
Diagnostic Category: Developmental or Congenital
Created: over 8 years ago
Updated: over 8 years ago
Tags: PEDS
Modality/Study Types: CT
Adobe32 PDF Imagej32 ImageJA


10 year old female with Fanconi anemia and headache.

Case Images


Fanconi Anemia

Clinical Notes

Bone marrow transplantation several years ago.


CT – Multiple intracranial calcifications mainly junctional but also in deep gray and white matter tracts.


Fanconi anaemia is an autosomal recessive disease characterised by congenital abnormalities, defective hematopoiesis, and a high risk of developing acute myeloid leukemia and certain solid tumors. Underlying defect is related to chromosomal fragility and defective DNA repair. Brain calcifications are seen in about 1% of CT examinations and often associated with hypoparathyroidism, pseudohypoparathyroidism, trisomy 21, mitochondrial defects, neurodegenerative disease, some tumors, infections, or bone marrow failure syndromes (such as Fanconi anemia, Revesz syndrome and other myelodysplastic diseases). A suggested explanation of intracranial calcifications in bone marrow failure syndromes is bleeding with subsequent dystrophic calcification related to altered blood cell morphology (inducing endothelial damage) and abnormal blood cell number (predisposing to bleeding).


Negron D, Colon-Castillo L, Morales-Melecio I, et al. Association of extensive brain calcifications, myleofibrosis, and retinopathy in a 12 year old child. Ped Dev Pathol (2008); 11:148-151.

Corporate Office: 616.363.7272, 3264 North Evergreen Drive, Grand Rapids, MI 49525

Spectrum Health Helen Devos Childrens Hospital GE HealthCare