Heather Borders, MD
over 3 years ago
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Joseph Junewick, MD FACR
|Diagnostic Category: Infectious-Inflammatory
|Created: over 5 years ago
|Updated: over 5 years ago
7 month old male with cough and history of chronic granulomatous disease of infancy.
CT – Axial images with mediastinal and lung windows show multifocal pleural-based nodular infiltrates.
Aspergillus causes a wide spectrum of illnesses in humans, including allergy, superficial infection related to local trauma, and invasive disease. The lung is the most frequent site of disease. The host immune system is a major determinant of which particular form of aspergillosis develops. Acute invasive pulmonary aspergillosis affects severely immunocompromised persons. Less acute invasive disease has been described in patients with AIDS, diabetes mellitus, alcoholism, chronic low dose steroid therapy and chronic granulomatous disease. Aspergilloma is another form of Aspergillus infection that involves preexisting pulmonary cavities. Local extension of disease into the chest wall, brachial plexus, or vertebral column is occasionally seen.
Denning DW, Riniotis K, Dobrashian R, et al. Chronic Cavitary and Fibrosing Pulmonary and Pleural Aspergillosis: Case Series, Proposed Nomenclature Change, and Review. Clin Infect Dis(2003); 37 (Supplement 3): S265-S280.