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Heather Borders, MD
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Multiple Exostosis Syndrome

Case Detail

Anatomy: Musculoskeletal
Joseph Junewick, MD FACR
Diagnostic Category: Neoplasia Benign
Created: over 10 years ago
Updated: over 10 years ago
Tags: PEDS
Modality/Study Types: CR
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13 year old with cough and fever.

Case Images


Multiple Exostosis Syndrome


CR – Multiple osteochondromas involving the humeri, scapulae and ribs.


Multiple exostosis syndrome (MES) is a polynomic entity and may be referred to as multiple hereditary osteochondromatosis, osteochondromatosis, diaphyseal aclasis, external chondromatosis among others. MES is an autosomal dominant disorder. Osteochondromas may appear in any portion of the skeleton but tend to be more numerous and larger near the fastest growing joints (wrists and knees); osteochondromas of the carpal bones, sesamoid bones, vertebrae and skull are rare. Fifty percent of patients with multiple exostosis syndrome have lesions in the ribs. Complications include fractures, pneumothorax, vascular or neural compression, and malignant transformation to chondrosarcoma.


Levine BD, Motamedi K, Chow K, Gold RH, et al. CT of Rib Lesions. AJR (2009); 193:5-13

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