Granuloma Annulare Elbow
Heather Borders, MD
over 5 years ago
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Coagulopathy of the Newborn
Joseph Junewick, MD FACR
|Diagnostic Category: Vascular
|Created: over 6 years ago
|Updated: over 6 years ago
1 day old with lethargy.
Coagulopathy of the Newborn,
Precipitous at home delivery. Vitamin K not administered.
CT – Large posterior fossa hematoma (hemispheric and extra-axial) with fluid-fluid level and obstructive hydrocephalus.
Neonatal bleeding results from disorders of platelets, coagulation proteins, and vascular integrity. While healthy newborns have low levels of some coagulation proteins, this is normally balanced by the paralleled decrease in fibrinolytic activity. Causes of neonatal bleeding may include platelet disorders (thrombocytopenia from syndromes, infection, consumption and hemolytic disease and abnormal platelet function from vonWillebrand disease and indomethicin therapy), deficient coagulation proteins (Hemophilia A, Hemophilia B, Factor V VII X XI or XII deficiency, afibrogenemia, and vitamin K deficiency), combined platelet and coagulation protein defects (disseminated intravascular coagulation, hepatic dysfunction), and abnormal sequestration (hemangiomas).
Hanigan WC, Powell FC, Palagallo G, Miller TC. Lobar Hemorrhages in fullterm neonates. Child Nerv Sys (1995); 11(5):276-280.