Hosting 728 files, 2951 images, and 4 contributors.

Random Case

Urethral Duplication
Joseph Junewick, MD FACR
over 11 years ago
Enter A Workflow
Standard2   Academic2

Please choose a workflow. A standard workflow allows you to browse the repository with full case detail; the academic workflow allows you to browse the repository with limited case detail revealed. Double click on the images to launch image viewer.

ARSt Case Repository

Hamartoma of the Tuber Cinereum

Case Detail

Anatomy: Brain-Spine
Joseph Junewick, MD FACR
Diagnostic Category: Neoplasia Benign
Created: over 10 years ago
Updated: over 10 years ago
Tags: PEDS
Modality/Study Types: MR
Adobe32 PDF Imagej32 ImageJA


3 year old with seizures.

Case Images


Hamartoma of the Tuber Cinereum


MR – Between the lamina terminalis and optic chiasm anteriorly and the mamillary bodies is focal thickening of the tuber cinereum which is iso- to hypointense on sagittal T1 image. Also note, thinning of the posterior corpus callosum and downward displacement of the cerebellar tonsils.


Hypothalamic hamartomas are developmental malformations consisting of tumorlike masses located in the tuber cinereum of the hypothalamus. Most patients present in the first or second decade of life, with boys being more commonly affected than girls. There are 2 types of hypothalamic hamartomas, parahypothalamic hamartomas and intra-hypothalamic hamartomas. Parahypothalamic hamartomas are pedunculated and associated with precocious puberty. Intrahypothalamic hamartomas are sessile masses with a broad attachment to the hypothalamus and are associated with gelastic seizures. At pathologic analysis, hypothalamic hamartomas contain nerve cells that resemble those of the normal hypothalamus, along with normal glial cells. At MR imaging hamartomas of the tuber cinereum are isointense or mildly hypointense on T1-weighted images and iso- to hyperintense on T2-weighted images, with no contrast enhancement or calcification. Stability of the lesion strongly supports the diagnosis of hypothalamic hamartoma.


Saleem SN, Said AM and Lee DH. Lesions of the Hypothalamus: MR Imaging Diagnostic Features. Radiographics (2007); 27:1087-1108.


John Quick MD

Corporate Office: 616.363.7272, 3264 North Evergreen Drive, Grand Rapids, MI 49525

Spectrum Health Helen Devos Childrens Hospital GE HealthCare