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Meningitis
Joseph Junewick, MD FACR
over 8 years ago
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ARSt Case Repository

Anaplastic Astrocytoma

Case Detail

Anatomy:
Junewick
Joseph Junewick, MD FACR
Diagnostic Category: Neoplasia Malignant
Created: over 8 years ago
Updated: over 6 years ago
Tags: PEDS
Modality/Study Types: MR CT
Activities:
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History

2 year old male with left upper extremity weakness.


Case Images


Diagnosis

Anaplastic Astrocytoma

Findings

CT – Large hypodense mass lesion in anterior right cerebrum with periventricular infiltration.

MR – T2 hyperintense right cerebral mass with little or no enhancement.

MRS – Diminished NAA and elevated lactate peaks.

Discussion

The designation of a tumor as anaplastic astrocytoma reflects a distinct histologic classification of malignant glioma characterized by an abundance of pleomorphic astrocytes and evidence of mitosis (WHO III). Although these tumors are malignant, they have a better prognosis and a higher likelihood of response to treatment than glioblastoma. Currently, most patients undergo maximal surgical debulking of tumor followed by external beam radiation and subsequent adjuvant chemotherapy.

Reference

See SJ, Gilbert MR. Anaplastic astrocytoma: diagnosis, prognosis and management. Semin Oncol. 2004 Oct;31(5):618-34.



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