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Joseph Junewick, MD FACR
over 10 years ago
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Anaplastic Astrocytoma

Case Detail

Joseph Junewick, MD FACR
Diagnostic Category: Neoplasia Malignant
Created: over 11 years ago
Updated: over 10 years ago
Tags: PEDS
Modality/Study Types: CT MR
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2 year old male with left upper extremity weakness.

Case Images


Anaplastic Astrocytoma


CT – Large hypodense mass lesion in anterior right cerebrum with periventricular infiltration.

MR – T2 hyperintense right cerebral mass with little or no enhancement.

MRS – Diminished NAA and elevated lactate peaks.


The designation of a tumor as anaplastic astrocytoma reflects a distinct histologic classification of malignant glioma characterized by an abundance of pleomorphic astrocytes and evidence of mitosis (WHO III). Although these tumors are malignant, they have a better prognosis and a higher likelihood of response to treatment than glioblastoma. Currently, most patients undergo maximal surgical debulking of tumor followed by external beam radiation and subsequent adjuvant chemotherapy.


See SJ, Gilbert MR. Anaplastic astrocytoma: diagnosis, prognosis and management. Semin Oncol. 2004 Oct;31(5):618-34.

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